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A cis-dominant regulatory mutation affecting enzyme induction in the enkaryote Aspergillus nidulans


STUDIES on cis-acting regulatory mutants (for example, operator and promoter mutants) in bacteria have been of crucial importance in understanding gene regulation1–4. Similar mutants in eukaryote systems have not been extensively studied although there have been two reports of probable operator constitutive mutants in yeast5,6. An understanding of eukaryote genetic organisation and gene regulation requires that mutants affecting the regulation of adjacent genes of defined function be isolated and characterised. This communication describes a mutant of Aspergillus nidulans that is altered in a site closely linked to the structural gene (amdS) for acetamidase (E.C.,8 and results in increased inducibility of this enzyme by acetamide. It is further shown that this mutation is cis-dominant in its effects.

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HYNES, M. A cis-dominant regulatory mutation affecting enzyme induction in the enkaryote Aspergillus nidulans. Nature 253, 210–212 (1975).

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