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Total human body protein synthesis in relation to protein requirements at various ages


THE intensity of body and tissue protein metabolism per kg declines with increased adult body size in mammals1. This fall parallels a similar progressive decline in the intensity of energy metabolism2–4. It has also been concluded that protein metabolism per unit of body weight is about four to five times faster in young rats than in adult man1; this pattern of change extends to cellular and subcellular aspects of protein metabolism, such as plasma albumin synthesis, liver RNA content and enzyme activity1,5. Similarly, the rate of protein synthesis per kg total body weight declines during growth and development within a species, such as the rat6. This parameter again parallels the reduction in the intensity of energy metabolism which occurs during the growth period3.

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  1. Munro, H. N., in Mammalian Protein Metabolism (edit. by Munro, H. N.), Vol. III, ch. 25, 133–182 (Academic Press, New York, 1969).

    Book  Google Scholar 

  2. Brody, S., Bioenergetics and Growth (Reinhold, New York, 1945).

    Google Scholar 

  3. Kleiber, M., The Fire of Life (John Wiley, New York, 1961).

    Google Scholar 

  4. Waterlow, J. C., Lancet, ii, 1091–1097 (1968).

    Article  CAS  Google Scholar 

  5. Young, V. R., in Mammalian Protein Metabolism (edit. by Munro, H. N.), Vol. IV, ch. 40, 585–674 (Academic Press, New York, 1970).

    Book  Google Scholar 

  6. Waterlow, J. C., and Stephen, J. M. L., Clin. Sci., 33, 489–506 (1967).

    CAS  PubMed  Google Scholar 

  7. Nicholson, J. F., Pediat. Res., 4, 389–397 (1970).

    Article  CAS  Google Scholar 

  8. Waterlow, J. C., in Mammalian Protein Metabolism (edit. by Munro, H, N.), Vol. III, ch. 28, 325–390 (Academic Press, New York, 1969).

    Book  Google Scholar 

  9. Sharp, C. S., Lassen, S., Shankman, S., Hazlet, J. W., and Kednis, M. S., J. Nutr., 63, 155–162 (1957).

    Article  CAS  Google Scholar 

  10. Picou, D., and Taylor-Roberts, T., Clin. Sci., 36, 283–296 (1969).

    CAS  PubMed  Google Scholar 

  11. Steffee, W. P., thesis (Massachusetts Institute of Technology, Cambridge, Mass. 02139, 1974).

  12. Pencharz, P. B., thesis, Massachusetts Institute of Technology, (1974).

  13. Picou, D., and Phillips, M., Am. J. clin. Nutr., 25, 1261–1265 (1972).

    Article  CAS  Google Scholar 

  14. Sprinson, D. B., and Rittenberg, D., J. biol. Chem., 180, 707–714 (1949).

    CAS  PubMed  Google Scholar 

  15. FAO/WHO, Energy and Protein Requirements, Tech. Rept Ser. No. 522 (World Health Organisation, Geneva, Switzerland, 1973).

  16. Altman, P. L., and Dittmer, D. S., in Metabolism, p. 345, (Fedn Am. Soc. exp. Biol., Bethesda, Maryland, 1968).

    Google Scholar 

  17. Holt, L. E., jun., and Snyderman, S. E., Nutr. Abstr. Revs., 35, 1–13 (1965).

    Google Scholar 

  18. Gaull, G., Sturman, J. A., and Räihä, N. C. R., Pediat. Res., 6, 538–457 (1972).

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YOUNG, V., STEFFEE, W., PENCHARZ, P. et al. Total human body protein synthesis in relation to protein requirements at various ages. Nature 253, 192–194 (1975).

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