Host range of murine xenotropic virus: replication in avian cells


AN endogenous C-type virus with an unusual tropism has been isolated from New Zealand Black (NZB) and other mouse strains. Although it has the murine leukaemia virus (MLV) gs-1 antigen and reverse transcriptase, it cannot be propagated in mouse cells. It is only infectious for cells foreign to the host species and has been termed xenotropic1–3. In the course of host range studies, we have discovered that, in contrast to other mammalian C-type viruses, this murine xenotropic virus can cross class barriers and both infect and replicate efficiently in avian cells. In these studies, the NZB pseudotype murine sarcoma virus (MSV) (Table 1) was used as it provides a good marker (focus formation) for NZB virus infection and replication.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Levy, J. A., and Pincus, T., Science, 107, 326–327 (1970).

    ADS  Article  Google Scholar 

  2. 2

    Levy, J. A., Science, 182, 1151–1153 (1973).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Levy, J. A., Am. J. clin. Path., 62, 258–280 (1974).

    CAS  Article  Google Scholar 

  4. 4

    Hartley, J. W., and Rowe, W. P., Proc. natn. Acad. Sci. U.S.A., 55, 780–786 (1966).

    ADS  CAS  Article  Google Scholar 

  5. 5

    Duc-Nguyen, H., J. Virol., 2, 643–644 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. 6

    Parkman, R., Levy, J. A., and Ting, R. C., Science, 168, 387–389 (1970).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Levy, J. A., and Rowe, W. P., Virology, 45, 844–847 (1971).

    CAS  Article  Google Scholar 

  8. 8

    Rowe, W. P., Pugh, W. E., and Hartley, J. W., Virology, 42, 1136–1139 (1970).

    CAS  Article  Google Scholar 

  9. 9

    Aaronson, S. A., and Todaro, G. J., Nature, 225, 458–459 (1970).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Klement, V., Freedman, M. H., McAllister, R. M., Nelson-Rees, W. A., and Huebner, R. J., J. natn. Cancer Inst., 47, 65–73 (1971).

    CAS  Google Scholar 

  11. 11

    Aaronson, S. A., Nature, 230, 445–447 (1971).

    ADS  CAS  Article  Google Scholar 

  12. 12

    Rhim, J. S., Vernon, M. L., Duh, F. G., and Huebner, R. J., Int. J. Cancer, 12, 734–741 (1973).

    CAS  Article  Google Scholar 

  13. 13

    Huang, A., Besmer, P., Chu, L., and Baltimore, D., J. Virol., 12, 659–662 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. 14

    Svoboda, J., and Klement, V., Folia Biol., 9, 403–410 (1963).

    CAS  Google Scholar 

  15. 15

    Svoboda, J., Donner, L., and Mach, O., Nature, 248, 503–505 (1974).

    ADS  CAS  Article  Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

LEVY, J. Host range of murine xenotropic virus: replication in avian cells. Nature 253, 140–142 (1975).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing