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Increased axoplasmic flow associated with pargyline under conditions which induce a myopathy


THE suggestion that an abnormality of the circulation might be important in the pathogenesis of Duchenne muscular dystrophy1–3 has been supported by the abnormal intrafibrillar fluorescence of muscle biopsies4, which is presumed to be due to the presence of catecholamines5. Accumulation of catecholamines, accompanied by the appearance of a myopathy, can be induced by the monoamine oxidase inhibitor pargyline5, while this myopathy can be prevented by sectioning of the sciatic nerve. This suggests that the induced myopathy is dependent on an intact nerve supply to the muscle and that catecholamines are involved in the process. Studying fast axoplasmic flow in rats treated with pargyline, we have obtained evidence of altered nerve function.

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BOEGMAN, R., WOOD, P. & PINAUD, L. Increased axoplasmic flow associated with pargyline under conditions which induce a myopathy. Nature 253, 51–52 (1975).

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