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Increased susceptibility to virus oncogenesis of congenitally thymus-deprived nude mice

Nature volume 252, pages 746–747 (1974)Cite this article

Abstract

A ROLE of thymus-deprived (T) lymphocytes in controlling tumour development has been widely discussed. The most convincing evidence in support of such a mechanism comes from observations on the induction of tumours by polyoma virus in adult mice1. Normal adult mice do not develop tumours after infection with the virus, but mice deprived of T lymphocytes by thymectomy and repeated inoculations of anti-lymphocytic serum and infected with polyoma virus as adults do develop tumours. If such animals are reconstituted with T lymphocytes from syngeneic immune donors, tumours do not develop.

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Authors and Affiliations

  1. MRC Clinical Research Centre, Watford Road, Harrow, Middlesex, HA1 3UJ, UK

    A. C. ALLISON, J. N. MONGA & V. HAMMOND

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  1. A. C. ALLISON
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  2. J. N. MONGA
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  3. V. HAMMOND
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ALLISON, A., MONGA, J. & HAMMOND, V. Increased susceptibility to virus oncogenesis of congenitally thymus-deprived nude mice. Nature 252, 746–747 (1974). https://doi.org/10.1038/252746a0

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