Abstract
CATTLE grazing the South American egg plant, Solanum malacoxylon, develop hypercalcaemia and hyperphosphataemia resulting in severe calcinosis1. The active principle in the plant stimulates intestinal calcium transport2–4 and bone mineral resorption2,4 in laboratory animals. It resembles vitamin D except that it is water soluble1,5 and exerts its initial action and declines in activity more rapidly2. Recent work6 suggests that the factor closely resembles 1,25-dihydroxycholecalciferol (1,25-(OH)2-D3), a metabolite of vitamin D3 formed in the kidney7, in that it overcomes the inhibition by dietary strontium8 of vitamin D3-induction of the intestinal calcium-binding protein (CaBP) and, concomitantly, calcium absorption9.
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References
Worker, N. A., and Carrillo, B. J., Nature, 215, 72–74 (1967).
Mautalen, C. A., Endocrinology, 90, 563–567 (1972).
O'Donnell, J. M., and Smith, M. W., Nature, 244, 357–358 (1973).
Campos, C., Ladizesky, M., and Mautalen, C., Calc. Tiss. Res., 13, 245–248 (1973).
Humphreys, D. J., Nature new Biol., 246, 155–157 (1973).
Wasserman, R. H., Science, 183, 1092–1094 (1974).
Lawson, D. E. M., Fraser, D. R., Kodicek, E., Morris, H. R., and Williams, D. H., Nature, 230, 228–230 (1971).
Omdahl, J. L., and DeLuca, H. F., J. biol. Chem., 247, 5520–5526 (1972).
Corradino, R. A., Ebel, J. G., Craig, P. H., Taylor, A. N., and Wasserman, R. H., Calc. Tiss. Res., 7, 81–92 (1971).
Corradino, R. A., J. Cell Biol., 58, 64–78 (1973).
Corradino, R. A., Science, 179, 402–405 (1973).
Corradino, R. A., and Wasserman, R. H., Science, 172, 731–733 (1971).
Corradino, R. A., Endocrinology, 94, 1607–1614 (1974).
Corradino, R. A., Taylor, A. N., and Wasserman, R. H., Fedn Proc., 28, 760 (1969).
Moriuchi, S., and DeLuca, H. F., Archs Biochem. Biophys., 164, 165 (1974).
Corradino, R. A., Nature, 243, 41–43 (1973).
Uribe, A., Holick, M. F., Jorgensen, N. A., and DeLuca, H. F., Biochem. biophys. Res. Commun., 58, 257–262 (1974).
Wasserman, R. H., and Taylor, A. N., Science, 152, 791–793 (1966).
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CORRADINO, R., WASSERMAN, R. 1,25-dihydroxycholecalciferol-like activity of Solanum malacoxylon extract on calcium transport. Nature 252, 716–718 (1974). https://doi.org/10.1038/252716a0
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DOI: https://doi.org/10.1038/252716a0
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