Trick or treat from food endocannabinoids?

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Beltramo and Piomelli reply — The two most abundant N-acylethanolamines (NAEs) found in chocolate (N-oleyl-ethanolamine and N-linoleylethanolamine) do not activate brain cannabinoid receptors but effectively inhibit anandamide degradation1,2. This observation suggested to us that these compounds might contribute to the hedonic properties of chocolate by causing non-metabolized anandamide to accumulate at its sites of action2.

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  1. 1

    Desarnaud, F., Cadas, H. & Piomelli, D. J. Biol. Chem. 270, 6030–6035 (1995).

  2. 2

    di Tomaso, E., Beltramo, M. & Piomelli, D. Nature 382, 677–678 (1996).

  3. 3

    Arnone, al. Psychopharmacol. 132, 104–106 (1997).

  4. 4

    Colombo, G. et al. Life Sci. 63, PL113-PL117 (1998).

  5. 5

    McGregor, I. et al. Proc. Int. Cannabinoid Res. Soc. Meet. 76 (1997).

  6. 6

    Di Marzo al. Nature 372, 686–691 (1994).

  7. 7

    Huxtable, R. J. Nature 382, 411–412 (1994).

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