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Echinomycin: a bifunctional intercalating antibiotic


The interaction between echinomycin and circular DNA or sonicated rod-like DNA fragments shows that this antibiotic binds by a bifunctional mode of intercalation. Binding parameters for a variety of natural and synthetic DNAs vary widely, indicating that echinomycin interacts selectively with specific nucleotide sequences.

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Waring, M., Wakelin, L. Echinomycin: a bifunctional intercalating antibiotic. Nature 252, 653–657 (1974).

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