Abstract
MALIGNANT cell transformation is associated with the appearance of abnormal chromosome patterns1. The degree to which malignant potential is expressed by transformed cells seems to depend on the balance between specific chromosomes responsible for the expression or suppression of malignancy2. Sachs et al.2-4 have demonstrated a relationship between these chromosomes and both oncogenic activity and cell membrane characteristics in transformed and reverted cells. Benedict et al.5, identified specific chromosomes associated with either expression or suppression of malignancy in hamster fibrosarcoma cells; tumorigenicity in different clones was related to the balance of these chromosomes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Benedict, W. F., Gielen, J. E., and Nebert, D. W., Int. J. Cancer, 9, 435–445 (1972).
Yamamoto, T., Rabinowitz, Z., and Sachs, L., Nature (in the press).
Inbar, M., Rabinowitz, Z., and Sachs, L., Int. J. Cancer, 4, 690–696 (1969).
Rabinowitz, A., and Sachs, L., Virology, 40, 193–198 (1970).
Benedict, W. F., Rucker, N., and Kouri, R. E. (in the press).
Haywood, G. R., and McKhann, C. F., J. exp. Med., 133, 1171–1187 (1971).
Rios, A., and Simmons, R. L., Cancer Res., 32, 16–21 (1972).
Paul, B., Porter, I. H., and Benedict, W. F., Humangenetik, 18, 185–187 (1973).
Hellström, I., and Hellström, K. E., in In Vitro Methods in Cell Mediated Immunity (edit. by Bloom, B. E., and Glade, P. R.), 409–414 (Academic Press, New York and London, 1971).
Harris, H., Miller, O. J., Klein, G., Worst, P., and Tachibana, T., Nature, 223, 363–368 (1969).
Hitotsumachi, S., Rabinowitz, Z., and Sachs, L., Nature, 231, 511–514 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CODISH, S., PAUL, B. Reversible appearance of a specific chromosome which suppresses malignancy. Nature 252, 610–612 (1974). https://doi.org/10.1038/252610a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/252610a0
This article is cited by
-
Abnormalities of chromosome No. 1: Significance in malignant transformation
Virchows Archiv B Cell Pathology (1978)
-
Chromosomenanomalien bei malignen Tumoren
Klinische Wochenschrift (1978)
-
Suppression of malignancy in human cells
Nature (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
