Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

The activity of membrane bound enzymes in muscular dystrophic chicks

Abstract

TISSUES from patients with Duchenne muscular dystrophy1 (DMD) as well as animals with similar inherited2 or experimentally produced3 disorders have been shown to undergo significant changes in the amount and composition of their membrane lipids. Most pronounced are the increases in cholesterol and sphingomyelin and the decrease in phosphatidyl choline levels. Functional anomalies observed in this disease, such as the impairment in sarcoplasmic reticulum calcium uptake4 or the changes in the ATPase activity of the sarcolemma5, can be related to the lipid disorder.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kunze, D., Reichmann, G., Egger, E., Leuschner, G., and Eckhardt, H., Clin. Chim. Acta, 43, 333 (1973).

    Article  CAS  PubMed  Google Scholar 

  2. Owens, K., and Hughes, B. P., J. Lipid Res., 11, 486 (1970).

    CAS  PubMed  Google Scholar 

  3. Albarracin, I., Lassaga, F. E., and Caputto, R., J. Lipid Res., 15, 89 (1974).

    CAS  PubMed  Google Scholar 

  4. Sreter, F. A., Martonosi, A., and Gergely, J., Fedn Proc., 23, 530 (1964).

    Google Scholar 

  5. Dhalla, N. S., McNamara, D. B., Balasubramanian, U., Green-law, R., Tucker, F. R., Res. Commun. Chem. Pathol Pharmacol., 6, 643 (1973).

    CAS  PubMed  Google Scholar 

  6. Matheson, D. W., and Howland, J. L., Science, 184, 165 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Brown, H. D., Chattopadhyay, S. K., and Patel, A. B., Science, 157, 1577 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Das, P. K., Watts, R. L., and Watts, D. C., Biochem. J., 123, 24p. (1971).

    Article  Google Scholar 

  9. King, B., and Emery, A. E. H., J. neurol. Sci., 20, 297 (1973).

    Article  CAS  PubMed  Google Scholar 

  10. Martonosi, A., Proc. Soc. exp. Biol. Med., 127, 824 (1968).

    Article  CAS  PubMed  Google Scholar 

  11. Hsu, Q. -S., and Kaldor, G., Proc. Soc. exp. Biol. Med., 131, 1398 (1969).

    Article  CAS  PubMed  Google Scholar 

  12. Rothfield, L., and Finkelstein, A., Ann. Rev. Biochem., 37, 463 (1968).

    Article  CAS  PubMed  Google Scholar 

  13. Pohl, S. L., Krans, H. M. J., Kozyreff, V., Birnbaumer, L., and Rodbell, M., J. biol. Chem., 246, 4447 (1971).

    CAS  PubMed  Google Scholar 

  14. Puchwein, G., Pfeuffer, T., and Helmreich, E. J. M., J. biol. Chem., 249, 3232 (1974).

    CAS  PubMed  Google Scholar 

  15. Severson, D. L., Drummond, G. I., Sulakhe, P. V., J. biol. Chem., 247, 2949 (1972).

    CAS  PubMed  Google Scholar 

  16. Salomon, Y., Londos, C., and Rodbell, M., Anal. Biochem., 58, 541–549 (1974).

    Article  CAS  PubMed  Google Scholar 

  17. Lowry, O. H., Rosenbrough, N. Y., Farr, A. L., and Randall, R. J., J. biol Chem., 193, 265 (1951).

    CAS  PubMed  Google Scholar 

  18. Neville, D. M., jun., Biochim. biophys. Acta, 154, 540 (1968).

    Article  CAS  PubMed  Google Scholar 

  19. Bilezikian, J. P., and Aurbach, G. D., J. biol. Chem., 249, 5575 (1973).

    Google Scholar 

  20. Ames, B. N., Methods in Enzymology VIII, 115 (1966).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

RODAN, S., HINTZ, R., SHA'AFI, R. et al. The activity of membrane bound enzymes in muscular dystrophic chicks. Nature 252, 589–591 (1974). https://doi.org/10.1038/252589a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/252589a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing