Letter | Published:

LSD as an agonist and antagonist at central dopamine receptors

Abstract

THE mechanisms involved in the psychotomimetic actions of D-lysergic acid diethylamide (D-LSD) and other hallucinogenic agents have not been defined. Neurophysiological and behavioural studies indicate that D-LSD may interact with serotonin and catecholamine receptors in the central nervous system. Thus, this drug seems to stimulate certain central serotonergic pathways1,2, while inhibiting the activation of other pathways by serotonin3,4.

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