Letter | Published:

LSD as an agonist and antagonist at central dopamine receptors

Nature volume 252, pages 588589 (13 December 1974) | Download Citation

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Abstract

THE mechanisms involved in the psychotomimetic actions of D-lysergic acid diethylamide (D-LSD) and other hallucinogenic agents have not been defined. Neurophysiological and behavioural studies indicate that D-LSD may interact with serotonin and catecholamine receptors in the central nervous system. Thus, this drug seems to stimulate certain central serotonergic pathways1,2, while inhibiting the activation of other pathways by serotonin3,4.

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  1. Department of Biological Chemistry, School of Medicine and the Brain Research Institute, University of California Center for the Health Sciences, Los Angeles, California 90024

    • KERN VON HUNGEN
    • , SIDNEY ROBERTS
    •  & DIANE F. HILL

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https://doi.org/10.1038/252588a0

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