Abstract
REMYELINATION within the central nervous system (CNS) is rarely seen in pathological material or in experimentally produced lesions and when it occurs it is a considerably slower process than its counterpart in the peripheral nervous system. It is generally thought that a major factor precluding central remyelination is the failure of oligodendroglia to undergo division1,2. As this hypothesis is difficult to test experimentally in the CNS, we have attempted to mimic the situation peripherally, and have examined the effects of inhibiting Schwann cell proliferation after peripheral demyelination. Here we report our preliminary results.
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HALL, S., GREGSON, N. The effects of mitomycin C on remyelination in the peripheral nervous system. Nature 252, 303–305 (1974). https://doi.org/10.1038/252303a0
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DOI: https://doi.org/10.1038/252303a0
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