Abstract
EVIDENCE exists indicating that functionally different subsets of T lymphocytes are activated during the in vitro allograft response. Thus, the T cells responding primarily by proliferation in the mixed lymphocyte culture (MLC) may be distinct from the T cells which differentiate to killer cells and display specific target cell lysis (CML)1–3. The biological properties of the T-cell subsets involved are incompletely known. Adult thymectomy (ATX) in mice and rats alters certain T lymphocyte mediated functions. Spleen T cells forming rosettes with sheep erythrocytes disappear as soon as 5 d after ATX4,5. Lymphocyte with high amounts of surface θ antigen are depleted from the spleen within a few weeks after the operation (Ref. 6 and C. Fournier and J. F. B., unpublished).
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References
Wagner, H., Rollinghöf, M., and Nossal, G., Transpln Rev., 17, 4 (1973).
Cohen, L., and Howe, N. L., Proc. natn. Acad. Sci. U.S.A., 70, 2707 (1973).
Häyry, P., and Andersson, L. C., Eur. J. Immun., 4, 145 (1974).
Bach, J. F., Dardenne, M., and Davies, A. J. S., Nature new Biol., 231, 110 (1971).
Bach, J. F., and Dardenne, M., Cell. Immun., 6, 394 (1974).
Schlesinger, M., and Yron, I., J. Immun., 104, 798 (1972).
Bach, J. F., Dardenne, M., and Bach, M. A., Ann. N. Y. Acad. Sci., (in the press).
Häyry, P., Andersson, L. C., Nordling, S., and Virolainen, M., Transpln Rev., 12, 91 (1972).
Julius, M. H., Simpson, E., and Herzenberg, L. A., Eur. J Immun., 3, 645 (1973).
Andersson, L. C., Nordling, S., and Häyry, P., J. exp. Med., 138, 324 (1973).
Andersson, L. V., Nordling, S., and Häyry, P., Scand. J. Immun., 2, 107 (1973).
Brunner, K. T., Mauel, J., Cerottini, J. C., and Chapuis, B., Immunology, 14, 181 (1968).
Bach, M. A., and Bach, J. F., Transpln Proc., 4, 165 (1972).
Schwarz, R., and Robson, L. C., Transplantation, 11, 465 (1971).
Folch, H., and Waksman, B., J. Immun., 5, 1046 (1972).
Howe, M., and Cohen, L., in Proc. 8th Leukocyte Culture Conf., (edit. by Lindahl-Kiessling, K., and Osoba, D.),611 (Academic Press, New York, 1974).
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ANDERSSON, L., HÄYRY, P., BACH, M. et al. Differences in the effects of adult thymectomy on T-cell mediated responses in vitro. Nature 252, 252–254 (1974). https://doi.org/10.1038/252252b0
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DOI: https://doi.org/10.1038/252252b0
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