Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Lithium treatment reduces morphine self-administration in addict rats

Abstract

RECENT reports suggest that opiate-seeking behaviour in experimentally-addicted animals can be reduced by administering other drugs, such as α-methyl-p-tyrosine and haloperidol1–4; and that haloperidol can also alleviate symptoms of heroin withdrawal in man5. Both drugs have been shown to reduce morphine-induced hyperactivity in mice6.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Pozuelo, J., and Kerr, F. W. L., Proc. Mayo Clinic, 47, 621–628 (1972).

    CAS  Google Scholar 

  2. Hanson, H. M., and Cimini-Venema, C. A., Fedn Proc., 3, 503 (1972).

    Google Scholar 

  3. Glick, S. D., Zimmerberg, B., and Charap, A. D., Psychopharmacologia, 32, 365–371 (1973).

    Article  CAS  Google Scholar 

  4. Schwartz, A. S., and Marchok, P. L., Nature, 248, 257–258 (1974).

    Article  ADS  CAS  Google Scholar 

  5. Karkalas, J., and Lal, H., Int. Pharmacopsychiat., 8, 248–251 (1973).

    Article  CAS  Google Scholar 

  6. Carroll, B. J., and Sharp, P. T., Science, 1972, 1355–1357 (1971).

    Article  ADS  Google Scholar 

  7. Carroll, B. J., and Sharp, P. T., Br. J. Pharmac., 46, 124–139 (1972).

    Article  CAS  Google Scholar 

  8. Sanghvi, I., and Gershon, S., Res. Comm. chem. Path. Pharmac., 6, 293–300 (1973).

    CAS  Google Scholar 

  9. Tulunay, F. C., Kiran, B. K., and Kaymakcalan, S., Acta med. Turc., 8, 51–60 (1971).

    CAS  Google Scholar 

  10. Kumar, R., Steinberg, H., and Stolerman, I. P., Nature, 218, 564–565 (1968).

    Article  ADS  CAS  Google Scholar 

  11. Stolerman, I. P., and Kumar, R., Psychopharmacologia, 17, 137–150 (1970).

    Article  CAS  Google Scholar 

  12. Khavari, K. A., and Risner, M. E., Psychopharmacologia, 30, 291–302 (1973).

    Article  CAS  Google Scholar 

  13. Tomkiewicz, M. Br. J. Pharmac., 44, 351P (1972).

    CAS  Google Scholar 

  14. Winer, B. J., Statistical Principles in Experimental Design (Mc-Graw-Hill, New York, 1962).

    Book  Google Scholar 

  15. Cox, C., Harrison-Read, P. E., Steinberg, H., and Tomkiewicz, M. Nature, 232, 336–338 (1971).

    Article  ADS  CAS  Google Scholar 

  16. Schou, M., J. psychiat. Res., 6, 67–95 (1968).

    Article  CAS  Google Scholar 

  17. Morrison, J. M., Pritchard, H. D., Braude, M. C., and D'Aguano, W., Proc. Soc. exp. Biol., 137, 887–892 (1971).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

TOMKIEWICZ, M., STEINBERG, H. Lithium treatment reduces morphine self-administration in addict rats. Nature 252, 227–229 (1974). https://doi.org/10.1038/252227a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/252227a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing