Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Molecular and crystal structure of deoxyguanosine 5′-phosphate


RECENT crystallographic studies of the dinucleosides ApU (ref. 1) and GpC (ref. 2) have given experimental proof for the base pairing arrangement proposed by Watson and Crick for the DNA double helix3. Another striking feature of this structure relates to the torsional angle about the C5′-C4′ bond in the phosphate–sugar backbone chain. In the Crick and Watson model4, this conformation is gauche–trans (GT). Crystal structures of 5′-nucleotides, dinucleosides and dinucleotides so far studied, however, have shown only the gauche–gauche (GG) conformation about this bond. The GG conformer is also the only one found in the refined models of the proposed structure of the double helical nucleic acids and polynucleotides5–7. The only nucleotide with a GT conformation is 6-azauridine-5′-phosphate8 which is not a normal monomer unit of nucleic acids. It is also reported that 5′-dGMP assumes preferentially GT conformation in solution9.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Rosenberg, J. M., Seeman, N. C., Kim, J. J. P., Suddath, F. L., Nicholas, H. B., and Rich, A., Nature, 243, 150 (1973).

    ADS  CAS  Article  Google Scholar 

  2. Day, R. O., Seeman, N. C., Rosenberg, J. M., and Rich, A., Proc. natn. Acad. Sci. U.S.A., 70, 849 (1973).

    ADS  CAS  Article  Google Scholar 

  3. Watson, J. D., and Crick, F. H. C., Nature, 171, 737 (1953).

    ADS  CAS  Article  Google Scholar 

  4. Crick, F. H. C., and Watson, J. D., Proc. R. Soc., A 223, 80 (1954).

    ADS  CAS  Google Scholar 

  5. Arnott, S., Dover, S. D., and Wonacott, A. J., Acta Cryst., B 25, 2192 (1969).

    CAS  Article  Google Scholar 

  6. Arnott, S., Prog. Biophys. molec. Biol., 21, 265 (1970).

    CAS  Article  Google Scholar 

  7. Arnott, S., Wilkins, M. H. F., Fuller, W., and Langridge, R., J. molec. Biol., 27, 535 (1967).

    CAS  Article  Google Scholar 

  8. Saenger, W., and Suck, D., Nature, 242, 610 (1973).

    ADS  CAS  Article  Google Scholar 

  9. Sarma, R. H., Mynott, R. J., Wood, D. J., and Hruska, F. W., J. Am. Chem. Soc., 95, 6457 (1973).

    CAS  Article  Google Scholar 

  10. Seshadri, T. P., and Viswamitra, M. A., Curr. Sci, 43, 111 (1974).

    CAS  Google Scholar 

  11. Germain, G., and Woolfson, M. M., Acta Cryst., B 24, 91 (1968).

    CAS  Article  Google Scholar 

  12. Viswamitra, M. A., Reddy, S., Lin, B. G. H-.Y., and Sundaralingam, M., J. Am. Chem. Soc., 93, 4565 (1971).

    CAS  Article  Google Scholar 

  13. Reddy, S. B., and Viswamitra, M. A., Cryst. Struct. Comm., 2, 9 (1973).

    CAS  Google Scholar 

  14. Trueblood, K. N., Horn, P., and Luzzati, V., Acta Cryst., 14, 965 (1961).

    CAS  Article  Google Scholar 

  15. Sundaralingam, M., Jerusalem Symp. Quant. Chem. Biochem., V, 417 (1973).

    Google Scholar 

  16. Young, D. W., Tollin, P., Wilson, H. R., Nature, 248, 513 (1974).

    ADS  CAS  Article  Google Scholar 

  17. Young, D. W., Tollin, P., Wilson, H. R., Acta Cryst., B 30, 2012 (1974).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

VISWAMITRA, M., SESHADRI, T. Molecular and crystal structure of deoxyguanosine 5′-phosphate. Nature 252, 176–177 (1974).

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI:

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing