Abstract
THE existence of a compartmented metabolism of glutamate in cerebral cortex is well established1,2. When, for example, glutamate, acetate or γ-aminobutyric acid (GA) are metabolised by the tissue the specific activity of the glutamine formed exceeds that of the total tissue glutamate pool. As the immediate precursor of glutamine is glutamate, the implication must be that there is more than one pool of the latter. A model consisting of a minimum of three compartments seems most compatible with available data and compartment 1, from which glutamine is rapidly formed, is thought to be located in glial cells1,2.
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KENNEDY, A., VOADEN, M. & MARSHALL, J. Glutamate metabolism in the frog retina. Nature 252, 50–52 (1974). https://doi.org/10.1038/252050a0
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DOI: https://doi.org/10.1038/252050a0
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