Abstract
CALCIUM regulates muscle contraction in all species which have been studied. Muscle relaxes in the absence of calcium and contracts when it is present in micromolar concentrations1–3. Contraction is caused by the interaction of myosin with ATP and with the actin of the thin filament, and the effect of calcium is to modulate this interaction1–8. Although these features apply to all muscles, the location of the calcium binding and thus the mechanism of its action differs in different phyla; regulation may be associated with the myosin, or the thin filaments or both2,3,7.
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MARSTON, S., LEHMAN, W. ADP binding to relaxed scallop myofibrils. Nature 252, 38–39 (1974). https://doi.org/10.1038/252038a0
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DOI: https://doi.org/10.1038/252038a0
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