WHEN tryptophan is administered to rats pretreated with a monoamine oxidase (MAO) inhibitor there results a characteristic syndrome of hyperactivity. This syndrome seems to be due to the increased synthesis and accumulation of the putative neurotransmitter 5-hydroxytryptamine (5-HT) and its ‘spill-over’ into functional activity which is presumably dependent on the stimulation of postsynaptic 5-HT receptors1. A qualitatively similar syndrome is produced by the administration of 5-methoxyN,N-dimethyltryptamine which, it has been suggested, directly stimulates 5-HT postsynaptic receptors2. This hyperactivity syndrome has been used to investigate the functional organisation of brain 5-hydroxytryptamine, the action of drugs such as chlorpromazine2, reserpine1 and lithium3 and to investigate the role of brain catecholamines4 in the mediation of brain 5-HT function.
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GREEN, A., GRAHAME-SMITH, D. TRH potentiates behavioural changes following increased brain 5-hydroxytryptamine accumulation in rats. Nature 251, 524–526 (1974). https://doi.org/10.1038/251524a0
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