Abstract
THE presence of infiltrating ‘histiocytic’, ‘mononuclear’ or ‘round’ cells (many of which may be cells of the monocyte/macrophage series) has often been observed in histological sections of certain types of human tumours and has been claimed to indicate good prognosis1,2. Evans, using a variety of functional criteria (such as adhesion to glass in the presence of trypsin and phagocytic ability) has shown that macrophages in tumour cell suspensions can be readily identified and quantitated3, and the macrophage contents of different experimental tumours were found to range from 4%–56% of the total cell population3. These cells were shown to be of host origin, most if not all being derived from circulating blood monocytes rather than by self-replication of macrophages within the tumour (Unpublished observation).
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ECCLES, S., ALEXANDER, P. Macrophage content of tumours in relation to metastatic spread and host immune reaction. Nature 250, 667–669 (1974). https://doi.org/10.1038/250667a0
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DOI: https://doi.org/10.1038/250667a0
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