Abstract
IMMUNOSUPPRESSION by passively administered antibody has long been known (see ref. 1 for review) and as antibody can cause enhancement of tumour growth2,3, particular attention has been paid to the role of antibody-mediated immunosuppression in tumour immunology. Hellstrom et al. have emphasised that blocking factors, most likely antigen-antibody complexes4, suppress cell-mediated immunity and thus play a major part in the progression of tumour growth5. Such blocking factors may be an important factor in the induction and/or maintenance of some forms of immunological tolerance6–8. But the mechanism remains obscure.
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GERSHON, R., MOKYR, M. & MITCHELL, M. Activation of suppressor T cells by tumour cells and specific antibody. Nature 250, 594–596 (1974). https://doi.org/10.1038/250594a0
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DOI: https://doi.org/10.1038/250594a0
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