Abstract
POLYAMINOCARBOXYLATE chelating agents such as ethylene-diaminetetraacetic acid (EDTA) form stable chelate complexes with the ions of many heavy metals. These metal ions exhibit a wide range of useful spectral and radioactive properties, such as electronic absorption, scattering of electrons and X rays, electron paramagnetic resonance spectra, the production of line-broadening and chemical shifts in nuclear magnetic resonance spectra, the emission of correlated gamma-ray cascades and various radioactive lifetimes and nuclear radiations. The preparation of chelating agents whose complexes can interact, in some selected manner, with biological macromolecules could make possible several new applications of metal ions as probes of biological systems.
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SUNDBERG, M., MEARES, C., GOODWIN, D. et al. Chelating agents for the binding of metal ions to macromolecules. Nature 250, 587–588 (1974). https://doi.org/10.1038/250587a0
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DOI: https://doi.org/10.1038/250587a0
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