Abstract
ALTHOUGH the chicken is more closely related to dinosaurs and crocodiles than to the mouse1, the clear-cut demarcation between thymus-derived (T) and bursa-derived (B) lymphocytes in this bird2,3 offers an excellent system for study of the two lymphocyte types. B cells have been demonstrated to possess surface immunoglobulin3–5, while T cells have not, although it has been established that light chains at least are expressed on specifically activated chicken T cells6. So far, however, intact polypeptide chains have not been demonstrated on T and B cells. We now describe the isolation and partial characterisation of surface immunoglobulins of chicken B and T lymphocytes. We have evidence that both lymphocyte types have surface immunoglobulins consisting of light chains, μ chains and a heavy chain of molecular weight 40,000.
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SZENBERG, A., CONE, R. & MARCHALONIS, J. Isolation of surface immunoglobulins from lymphocytes from chicken thymus and bursa. Nature 250, 418–420 (1974). https://doi.org/10.1038/250418a0
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DOI: https://doi.org/10.1038/250418a0
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