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The ageing, growth and death of cells

Abstract

The ageing and death of cells in higher plants and higher animals is discussed in relation to cellular rejuvenation by growth and division.

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References

  1. Orgel, L. E., Proc. natn. Acad. Sci. U.S.A., 49, 517–521 (1963).

    Article  ADS  CAS  Google Scholar 

  2. Orgel, L. E., Nature, 243, 441–445 (1973).

    Article  ADS  CAS  Google Scholar 

  3. Smith, J. M., Proc. R. Soc., B., 157, 115–127 (1963).

    Google Scholar 

  4. Strehler, B. L., Adv. gerontol. Res., 1, 343–384 (1964).

    CAS  Google Scholar 

  5. Goldfisher, S., Villaverde, H., and Forschirm, R., J. Histochem. Cytochem., 14, 641–652 (1966).

    Article  Google Scholar 

  6. Bjorkend, S., Adv. gerontol. Res., 1, 257–288 (1964).

    Google Scholar 

  7. Zeman, W., Adv. gerontol. Res., 3, 147–170 (1971).

    CAS  PubMed  Google Scholar 

  8. Barber, A. A., and Bernheim, F., Adv. gerontol. Res., 2, 355–403 (1967).

    CAS  PubMed  Google Scholar 

  9. Slater, T. F., Free Radical Mechanisms in Tissue Injury (Pion Ltd, London, 1972).

    Google Scholar 

  10. Dormandy, T. L., Lancet, ii, 684–688 (1969).

    Article  Google Scholar 

  11. Abraham, S. J., and Holtzman, E., J. Cell Biol., 56, 540–558 (1973).

    Article  Google Scholar 

  12. Geuze, J. G., and Pont, C., J. Cell Biol., 57, 159–174 (1973).

    Article  CAS  Google Scholar 

  13. Heuser, J. E., and Reese, T. S., J. Cell Biol., 57, 315–344 (1973).

    Article  CAS  Google Scholar 

  14. Orci, L., Malisse-Lagae, F., Ravazzola, M., and Amherdt, M., Science, 181, 561–562 (1973).

    Article  ADS  CAS  Google Scholar 

  15. Priestley, J. H., and Scott, L. I., An Introduction to Botany (Longmans, Green and Co., London, 1938).

    Google Scholar 

  16. Minot, C. S., The Problem of Age, Growth and Death (John Murray, London, 1908).

    Google Scholar 

  17. Glücksmann, A., Biol. Rev., 26, 59–86 (1951).

    Article  Google Scholar 

  18. Menkes, B., Sandor, S., and Ilies, A., Adv. Teratol., 4, 169–215 (1970).

    Google Scholar 

  19. Glücksmann, A., Archs Biol., 76, 419–437 (1965).

    Google Scholar 

  20. Saunders, J. W., Science, 154, 604–612 (1966).

    Article  ADS  Google Scholar 

  21. Broun, W. F., J. Neurol. Neurosurg. Psychiat., 35, 845–852 (1972).

    Article  Google Scholar 

  22. Brody, H., J. comp. Neurol., 102, 511–556 (1955).

    Article  CAS  Google Scholar 

  23. Quastler, H., and Sherman, F. G., Expl Cell Res., 17, 420–438 (1959).

    Article  CAS  Google Scholar 

  24. Harris, J. W., and Kellermeyer, R. W., The Red Cell (Harvard University Press, Cambridge, Mass., 1970).

    Google Scholar 

  25. Maloney, M. A., Patt, H. M., and Lund, J. E., Cell Tissue Kinet., 4, 201–209 (1971).

    Google Scholar 

  26. Metcalf, D., in The Thymus (edit. by Wolstenholme, G. E. W., and Porter, R.), 242–263 (Churchill, London, 1966).

    Book  Google Scholar 

  27. Pushin, R. W., and Harven, E., J. Cell Biol., 50, 583–597 (1971).

    Article  Google Scholar 

  28. Biggers, J. D., in Cellular Injury (edit. by de Reuck, A. V. S., and Knight, J.), 329–349 (Churchill, London, 1964).

    Google Scholar 

  29. Maheshwari, P., An Introduction to the Embryology of the Angiosperms (McGraw Hill, New York, 1950).

    Book  Google Scholar 

  30. Odor, D. L., Am. J. Anat., 97, 461–492 (1955).

    Article  CAS  Google Scholar 

  31. Odor, D. L., and Renninger, D. F., Anat. Rec., 137, 13–23 (1960).

    Article  CAS  Google Scholar 

  32. Wooding, F. B. P., J. Cell. Sci., 9, 805–821 (1971).

    CAS  PubMed  Google Scholar 

  33. Jacoby, F., in Cells and Tissues in Culture, II (edit. by Willmer, E. N.), 1–93 (Academic Press, London, 1965).

    Google Scholar 

  34. Biberfield, P., Expl Cell Res., 66, 433–445 (1971).

    Article  Google Scholar 

  35. Blough, H. A., and Tiffany, J. M., Adv. Lipid Res., 11, 267–239 (1973).

  36. Gross, L., Oncogenic Viruses 2nd ed. (Pergamon Press, Oxford, 1970).

    Google Scholar 

  37. Lieber, M. M., Benveniste, R. E., Livingston, D. M., and Todaro, G. J., Science, 182, 56–59 (1973).

    Article  ADS  CAS  Google Scholar 

  38. Sunderland, N., Ann. Bot., 31, 573–591 (1967).

    Article  CAS  Google Scholar 

  39. Street, H. E., King, P. J., and Mansfield, K. J., in Les Cultures de Tissus des Plantes (Colloques Internationaux du Centre National de la Récherche Scientifique No. 193), 17–40 (CNRS, Paris, 1971).

    Google Scholar 

  40. Short, K. C., and Torrey, J. G., J. exp. Bot., 23, 1099–1105 (1972).

    Article  CAS  Google Scholar 

  41. Hayflick, L., Expl Cell Res., 37, 614–636 (1965).

    Article  CAS  Google Scholar 

  42. McHale, J. S., Mouton, M. L., and McHale, J. T., Expl. Geront., 6, 89–93 (1971).

    Article  CAS  Google Scholar 

  43. Miyamoto, H., Zeuthen, E., and Rasmussen, L., J. Cell Sci., 13, 879–888 (1973).

    CAS  PubMed  Google Scholar 

  44. Bullough, W. S., and Deol, J. U. R., Symp. Soc. exp. Biol., 25, 255–275 (1971).

    CAS  PubMed  Google Scholar 

  45. Glücksmann, A., in Recent Advances in Clinical Pathology (edit. by Dyke, S. C.), 338–349 (Churchill, London, 1947).

    Google Scholar 

  46. Cooper, E. H., Cell Tissue Kinet., 6, 87–95 (1973).

    CAS  PubMed  Google Scholar 

  47. Kerr, J. F. R., and Searle, J., J. Path., 107, 41–44 (1972).

    Article  CAS  Google Scholar 

  48. Kerr, J. F. R., Wyllie, A. H., and Currie, A. R., Br. J. Cancer, 26, 239–257 (1972).

    Article  CAS  Google Scholar 

  49. Steel, G. G., Cell Tissue Kinet., 1, 193–207 (1968).

    Google Scholar 

  50. Gavosto, F., and Pileri, A., in The Cell Cycle and Cancer (edit. by Baserga, R.) (Dekker, New York, 1971).

    Google Scholar 

  51. Tarin, D., Br. J. Cancer, 23, 417–425 (1969).

    Article  CAS  Google Scholar 

  52. Sheldrake, A. R., Biol. Rev., 48, 508–559 (1973).

    Article  Google Scholar 

  53. Bessis, M., in Cellular Injury (edit. by de Reuck, A. V. S., and Knight, J.), 287–316 (Churchill, London, 1964).

    Google Scholar 

  54. Majno, G., in Cellular Injury (edit. by de Reuck, A. V. S., and Knight, J.), 87–98 (Churchill, London, 1964).

    Google Scholar 

  55. Teir, H., Lahtiharju, A., Alho, A., and Forsell, K-J., in Control of Cellular Growth in Adult Organisms (edit. by Tier, H., and Rytömaa, T.), 67–82 (Academic Press, London, 1967).

    Google Scholar 

  56. Vasiliev, J. M., and Guelstein, V. I., Prog. exp. Tumor Res., 8, 26–65 (1966).

    Article  CAS  Google Scholar 

  57. Sheldrake, A. R., Theoria to Theory, 7, (3) 31–38 (1973).

    Google Scholar 

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Sheldrake, A. The ageing, growth and death of cells. Nature 250, 381–385 (1974). https://doi.org/10.1038/250381a0

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