Abstract
THE use of antisera with specificity for cell surface antigens of T and B lymphocytes has become an increasingly important tool in cellular immunology, being extensively used both preparatively, and analytically1,2. Very little is known, however, about the possibilities of variation in antibody-induced cytotoxicity during the various stages of the cell cycle of normal T and B lymphocytes. Studies mostly examining histocompatability or virus-associated antigens on synchronised cell cultures of various tumour cell lines have yielded conflicting findings; in some cases cells seem to be most sensitive to antibody and complement during mitosis and perhaps early G13–5, whereas in others, the target cells have been judged to be insensitive in all phases except G16,7.
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KERBEL, R., DOENHOFF, M. Resistance of mitotic B lymphocytes to cytotoxic effects of anti-Ig serum. Nature 250, 342–344 (1974). https://doi.org/10.1038/250342a0
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DOI: https://doi.org/10.1038/250342a0
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