Abstract
IDIOPATHIC haemochromatosis (IHC) is generally considered to result from an inherited abnormality of iron metabolism in which excess iron accumulates in tissues such as liver, heart and pancreas, causing structural and functional abnormalities1. The clinical and pathological features of the disease have been well characterised1,2 although the mode of inheritance is uncertain because of the lack of a reliable genetic marker. In spite of several theories3–11, the metabolic abnormality leading to excess iron storage remains unknown.
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POWELL, L., ALPERT, E., ISSELBACHER, K. et al. Abnormality in tissue isoferritin distribution in idiopathic haemochromatosis. Nature 250, 333–335 (1974). https://doi.org/10.1038/250333a0
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DOI: https://doi.org/10.1038/250333a0
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