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Effect of a protein-free diet on mitotic activity of transplanted splenic lymphocytes


THE graft versus host reaction (GvHR) is initiated by donor thymus-derived lymphocytes1–3, and, the defence reaction of the host seems to be influenced by the extent of host lymphoid tissue4,5. Dietary protein deprivation provokes an involution of the lymphoid organs, mainly of the thymus and of the thymus-dependent fraction of blood and lymphoid tissue lymphocytes6,7. It is therefore of interest to know if a protein-free diet given to donors of a spleen graft inhibits the GvHR reactivity of the grafted lymphocytes, and if the same diet given to recipients lowers the capacity of these animals to react against the grafted cells.

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ASCHKENASY, A. Effect of a protein-free diet on mitotic activity of transplanted splenic lymphocytes. Nature 250, 325–327 (1974).

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