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Chronic response of dogs to parathyroid hormone infusion

Abstract

WHEN parathyroid hormone is infused chronically at a near-physiological rate, it causes hypercalcaemia by a mechanism fundamentally different from that which follows acute injections. Hormones, like drugs, have characteristic rates of metabolism and excretion and their distribution in the body is affected by binding to plasma proteins and membranes. Thus similar dependence of the pattern of response on entry rate is to be expected in the case of other hormones with short half lives, acting on multiple receptors of varying sensitivity.

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PARSONS, J., REIT, B. Chronic response of dogs to parathyroid hormone infusion. Nature 250, 254–257 (1974). https://doi.org/10.1038/250254a0

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