Abstract
THE primary response to human serum albumin (HSA) in the 6 to 10-week-old fowl is characterised by an early and accelerating rise in antibody level to a peak at about 9 d followed by an abrupt decline1. Comparison of the kinetics of this decline from the peak gave a close correspondence between it and the curve of decline of passively transfused labelled homologous 7S immunoglobulin. It seems clear that antibody production has been switched off before the peak and little ensues thereafter. The primary haemagglutinin response to sheep erythrocytes has a similar shape but the peak is earlier (Fig. 1)2. The in vivo suppressive effect is attributed to the negative feedback inhibition of the 7S antibody product and is thought to operate by the process of segregation of B cells into germinal centres2.
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NIELSEN, K., WHITE, R. Effect of host decomplementation on homeostasis of antibody production in fowl. Nature 250, 234–236 (1974). https://doi.org/10.1038/250234a0
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DOI: https://doi.org/10.1038/250234a0
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