Abstract
The specific abrogation of an established immune response was studied by removing in vivo most of the immuno-competent lymphocytes reactive against the specific antigen, thus restoring the animal to a state of specific immunological virginity.
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References
Mitchison, N. A., Transplant Proc., 3, 953 (1971).
Brent, L., Transplant Proc., 4, 363 (1972).
Feldman, J. D., Adv. Immun., 15, 167 (1972).
Hellstrom, I., and Hellstrom, K. E., Nature, 230, 49 (1971).
Sjöogren, H. O., Hellstrom, I., Bansal, S. C., and Hellstrom, K. E., Proc. natn. Acad. Sci. U.S.A., 68, 1372 (1971).
Lascelles, A. K., and Morris, B., Q. Jl exp. Physiol., 46, 199 (1961).
Hall, J. G., Morris, B., Moreno, G. D., and Bessis, M., J. exp. Med., 125, 91 (1967).
Taussig, M. J., and Lachmann, P. J., Immunology, 22, 185 (1972).
Iverson, G. M., in Handbook of Experimental Immunology (edit. by Weir, D. M.), 2nd ed., 29, (1973).
Mitchison, N. A., Eur. J. Immun., 1, 10 (1971).
Farr, R. S., J. infect. Dis., 103, 239 (1958).
Brownstone, A., Mitchison, N. A., and Pitt-Rivers, R., Immunology, 10, 465 (1966).
Hay, J. B., Cahill, R. S., and Trnka, Z., Cellular Immunology (in the press).
Uhr, J. W., and Pappenheimer, A. M., jun., J. exp. Med., 108, 891 (1958).
Unanue, E. R., and Cerrotini, J. C., J. exp. Med., 131, 711 (1970).
Smith, J. B., and Morris, B., Austr. J. exp. Biol. med. Sci., 48, 33 (1970).
Marchesi, V. P., and Gowans, J. L., Proc. R. Soc., B 159, 283 (1963).
Ford, W. L., and Atkins, R. C., Nature new Biol., 234, 178 (1972).
Sprent, J., and Miller, J. F. A. P., J. exp. Med., 138, 143 (1973).
Rowley, D. A., Gowans, J. L., Atkins, R. C., Ford, W. L., and Smith, M. E., J. exp. Med., 136, 499 (1972).
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McConnell, I., Lachmann, P. & Hobart, M. Restoration of specific immunological virginity. Nature 250, 113–116 (1974). https://doi.org/10.1038/250113a0
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DOI: https://doi.org/10.1038/250113a0
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