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Inhibition and reversal of capping by cytochalasin B, yinblastine and colchicine

Abstract

THE phenomenon of capping in lymphocytes1–4 consists of the segregation of membrane components, specifically cross-linked by antibody or other ligand, at one pole of the cell, typically that surrounding the centrosome1,2. Capping has been interpreted as resulting from a countercurrent flow of membrane components, in which the cross-linked patches are transported towards the centrosome region by interaction with cytoplasmic structures, while the unaffected parts of the membrane flow in the opposite direction1,2,5.

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DE PETRIS, S. Inhibition and reversal of capping by cytochalasin B, yinblastine and colchicine. Nature 250, 54–56 (1974). https://doi.org/10.1038/250054a0

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