Mutant of bacteriophage T4D affecting expression of many early genes

Abstract

IN T4 infections the mechanisms determining the time and rates of expression of early genes are not yet clearly understood. Although mutants which do not make late gene products or which are defective in DNA synthesis generally fail to turn off the synthesis of most early gene products, no mutations have been described which affect either the time of appearance or the initial rate of synthesis of proteins from more than a single early gene. This preliminary report describes the isolation and some of the properties of such a mutation. This mutation which maps between genes 52 and t defines a new regulatory gene.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Wiberg, J. S., Dirksen, M. L., Epstein, R. H., Luria, S. E., and Buchanan, J. M., Proc. natn. Acad. Sci. U.S.A., 48, 293–302 (1962).

  2. 2

    Mattson, T., and Russel, M., Virology, 49, 160–167 (1972).

  3. 3

    Josslin, R., Virology, 44, 101–107 (1971).

  4. 4

    Warner, H. R., and Hobbs, M. D., Virology, 33, 376–384 (1967).

  5. 5

    Young, E. T., II, Cold Spring Harbor Symp. quant. Biol., 35, 189–195 (1970).

  6. 6

    Hosoda, J., and Levinthal, C., Virology, 34, 709–727 (1968).

  7. 7

    Warner, H. R., and Lewis, N., Virology, 29, 172–175 (1966).

  8. 8

    Schmidt, D. A., Mazaitis, A. J., Kasai, T., and Bautz, E. H. F., Nature, 225, 1012–1016 (1970).

  9. 9

    Travers, A. A., Nature, 225, 1009–1012 (1970).

  10. 10

    Bolle, A., Epstein, R. H., Salzer, W., and Geiduschek, E. P., J. molec. Biol., 31, 325–348 (1968).

  11. 11

    Steinberg, C., and Edgar, R. S., Genetics, 47, 187–208 (1962).

  12. 12

    Laemmli, U. K., Nature, 227, 680–685 (1970).

  13. 13

    Fairbanks, G., jun., Levinthal, C., and Reeder, R. H., Biochem biophys. Res. Commun., 20, 393–399 (1965).

  14. 14

    O'Farrell, P. Z., Gold, L. M., and Huang, W. M., J. biol. Chem., 248, 5549–5501 (1973).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

MATTSON, T., RICHARDSON, J. & GOODIN, D. Mutant of bacteriophage T4D affecting expression of many early genes. Nature 250, 48–50 (1974). https://doi.org/10.1038/250048a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.