Mutant of bacteriophage T4D affecting expression of many early genes


IN T4 infections the mechanisms determining the time and rates of expression of early genes are not yet clearly understood. Although mutants which do not make late gene products or which are defective in DNA synthesis generally fail to turn off the synthesis of most early gene products, no mutations have been described which affect either the time of appearance or the initial rate of synthesis of proteins from more than a single early gene. This preliminary report describes the isolation and some of the properties of such a mutation. This mutation which maps between genes 52 and t defines a new regulatory gene.

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MATTSON, T., RICHARDSON, J. & GOODIN, D. Mutant of bacteriophage T4D affecting expression of many early genes. Nature 250, 48–50 (1974).

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