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Computer-aided three-dimensional reconstruction and quantitative analysis of cells from serial electron microscopic montages of foetal monkey brain

Abstract

Computer-aided reconstruction of immature brain cells with highly irregular shapes from serial electron microscopic montages gives three-dimensional images and quantitative data on surface areas and volumes, providing new classes of data on cell behaviour during development.

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References

  1. Golgi, C., Sulla fina anatomia degli organi centrali del sistema nervoso, 1883, republished in Opera Omnia (Hoepli, Milan, 1903).

    Google Scholar 

  2. Scheibel, M. E., and Scheibel, A. B., Int. Rev. Neurobiol., 13, 1 (1970).

    Article  Google Scholar 

  3. Wann, D. F., Woolsey, T. A., Dierker, M. L., and Cowan, W. M., Inst. Elect. Electron. Engng, Trans. Biomed. Engng, 20, 233 (1973).

    CAS  Google Scholar 

  4. Levinthal, C., and Ware, R., Nature, 236, 207 (1972).

    Article  ADS  Google Scholar 

  5. Macagno, E. R., Lopresti, V., and Levinthal, C., Proc. natn. Acad. Sci. U.S.A., 70, 57 (1973).

    Article  CAS  ADS  Google Scholar 

  6. Rakic, P., J. comp. Neurol., 145, 61 (1972).

    Article  CAS  Google Scholar 

  7. Boulder Committee, Anat. Rec., 166, 257 (1970).

  8. Willey, T. J., Schultz, R. L., and Gott, A. H., Inst. Elect. Electron. Engng, Trans. Biomed. Engng, 20, 288 (1973).

    CAS  Google Scholar 

  9. Stensaas, L. J., and Stensaas, S. S., Z. Zellforsch., 91, 341 (1968).

    Article  CAS  Google Scholar 

  10. Rakic, P., Brain Res., 33, 471 (1971).

    Article  CAS  Google Scholar 

  11. Bray, D., and Bunge, M. B., Locomotion of Tissue Cells, Ciba Foundation Symp., 14, 195 (1973).

    CAS  Google Scholar 

  12. Sjöstrand, F. S., J. ultrastruct. Res., 2, 122 (1958).

    Article  Google Scholar 

  13. Karlsson, U., J. ultrastruct. Res., 16, 482 (1966).

    Article  CAS  Google Scholar 

  14. Rakic, P., Science, 183, 425 (1974).

    Article  CAS  ADS  Google Scholar 

Download references

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Rakic, P., Stensas, L., Sayre, E. et al. Computer-aided three-dimensional reconstruction and quantitative analysis of cells from serial electron microscopic montages of foetal monkey brain. Nature 250, 31–34 (1974). https://doi.org/10.1038/250031a0

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