Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Clonal cell lines from the rat central nervous system

Abstract

Five neuronal and a large collection of putative glial cell lines from the rat central nervous system have been established in clonal cell culture and partially characterised. These cells shed new light on the distribution of neurotransmitter synthesis and brain-specific antigens among nerve and glia.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Augusti-Tocco, G., and Sato, G., Proc. natn. Acad. Sci. U.S.A., 64, 311 (1969).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Schubert, D., Humphreys, S., Baroni, C., and Cohn, M., Proc. natn. Acad. Sci. U.S.A., 64, 316 (1969).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Benda, P., Lightbody, J., Sato, G., Levine, L., and Sweet, W., Science, 161, 370 (1968).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Lightbody, J., Pfeiffer, S. E., Kornblith, P. L., and Herschman, H. R., J. Neurobiol., 1, 411 (1970).

    CAS  Article  Google Scholar 

  5. 5

    Pfeiffer, S. E., and Wechsler, W., Proc. natn. Acad. Sci. U.S.A., 69, 2885 (1972).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Druckrey, H., Preussmann, R., Ivankovic, S., and Schmahl, D., Z. Krebsforch., 69, 103 (1967).

    CAS  Article  Google Scholar 

  7. 7

    Vogt, M., and Dulbecco, R., Proc. natn. Acad. Sci. U.S.A., 49, 171 (1963).

    ADS  CAS  Article  Google Scholar 

  8. 8

    Kuffler, S. W., and Nicholls, J. G., Ergeb. Physiol., 57, 1 (1966).

    CAS  Article  Google Scholar 

  9. 9

    Steinbach, J. H., Harris, A. J., Patrick, J., Schubert, D., and Heinemann, S., J. gen. Physiol., 62, 255 (1973).

    CAS  Article  Google Scholar 

  10. 10

    Schubert, D., Harris, A. J., Heinemann, S., Kidokoro, Y., Patrick, J., and Steinbach, J. H., in Tissue culture of the nervous system (edit. by Sato, G.) 55–86 (Plenum, New York, 1973).

    Book  Google Scholar 

  11. 11

    Patrick, J., Heinemann, S., Lindstrom, J., Schubert, D., and Steinbach, J. H., Proc. natn. Acad. Sci. U.S.A., 69, 2762 (1972).

    ADS  CAS  Article  Google Scholar 

  12. 12

    Seeds, N. W., Gilman, A. G., Amano, T., and Nirenberg, M. W., Proc. natn. Acad. Sci. U.S.A., 66, 160 (1970).

    ADS  CAS  Article  Google Scholar 

  13. 13

    Furmanski, P., Silverman, D. J., and Lubin, M., Nature, 233, 413 (1971).

    ADS  CAS  Article  Google Scholar 

  14. 14

    Schubert, D., Humphreys, S., de Vitry, F., and Jacob, F., Devl Biol., 25, 514 (1971).

    CAS  Article  Google Scholar 

  15. 15

    Shapiro, D. L., Nature, 241, 203 (1973).

    ADS  CAS  Article  Google Scholar 

  16. 16

    Waymire, J. C., Bjur, R., and Weiner, N., Analyt. Biochem., 43, 588 (1971).

    CAS  Article  Google Scholar 

  17. 17

    Wilson, S. H., Schrier, B. K., Farber, J. L., Thompson, E. J., Rosenberg, R. N., Blume, A. J., and Nirenberg, M. W., J. biol. Chem., 247, 3159 (1972).

    CAS  Google Scholar 

  18. 18

    Coggeshall, R. E., Dewhurst, S. A., Weinreich, D., and McCaman, R. E., J. Neurobiol., 3, 259 (1972).

    CAS  Article  Google Scholar 

  19. 19

    Schubert, D., Tarikas, H., Harris, A. J., and Heinemann, S., Nature new Biol., 233, 79 (1971).

    CAS  Article  Google Scholar 

  20. 20

    Bevan, S., Miledi, R., and Grampp, W., Nature new Biol., 241, 85 (1973).

    ADS  CAS  Article  Google Scholar 

  21. 21

    Cicero, T. J., Cowan, W. M., Moore, B. W., and Suntzeff, V., Brain Res., 18, 25 (1970).

    CAS  Article  Google Scholar 

  22. 22

    Perez, V. J., Olney, J., Cicero, T. J., Moore, B. W., and Bahn, B. A., J. Neurochem., 17, 511 (1970).

    CAS  Article  Google Scholar 

  23. 23

    Packman, P. M., Blomstrand, C., and Hamberger, A., J. Neurochem., 18, 479 (1971).

    CAS  Article  Google Scholar 

  24. 24

    Haglid, K. G., Carlsson, G. A., and Stavron, D., Acta Neuropath. Berl. 24, 187 (1973).

    CAS  Article  Google Scholar 

  25. 25

    Hyden, H., and McEwen, B., Proc. natn. Acad. Sci. U.S.A., 55, 354 (1966).

    ADS  CAS  Article  Google Scholar 

  26. 26

    Sviridov, S. M., Korochkin, L. I., Ivanov, V. N., Maletskaya, E. I., and Bakhtina, T. K., J. Neurochem., 19, 713 (1972).

    CAS  Article  Google Scholar 

  27. 27

    Pfeiffer, S. E., Herschman, H. R., Lightbody, J., and Sato, G., J. cell. comp. Physiol., 75, 329 (1970).

    CAS  Article  Google Scholar 

  28. 28

    Blume, A., Gilbert, F., Wilson, S., Farber, J., Rosenberg, R., and Nirenberg, M., Proc. natn. Acad. Sci. U.S.A., 67, 786 (1970).

    ADS  CAS  Article  Google Scholar 

  29. 29

    Odell, W. D., and Daughaday, W. H., Principles of competitive protein-binding assays, (Lippincott, Philadelphia and Toronto, 1971).

    Google Scholar 

  30. 30

    Herschman, H. R., Levine, L., and DeVellis, J., J. Neurochem., 18, 629 (1971).

    CAS  Article  Google Scholar 

  31. 31

    Cicero, T. J., and Provine, R. R., Brain Res., 44, 294 (1972).

    CAS  Article  Google Scholar 

  32. 32

    Eastoe, J. E., in Treatise on collagen (edit. by Ramachandran, G. N.) 1, 1–72 (Academic Press, New York, 1967).

    Google Scholar 

  33. 33

    Schubert, D., Tarikas, H., Humphreys, S., Heinemann, S., and Patrick, J., Devl Biol., 33, 18 (1973).

    CAS  Article  Google Scholar 

  34. 34

    Amano, T., Richelson, E., and Nirenberg, M., Proc. natn. Acad. Sci. U.S.A., 69, 258 (1972).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Schubert, D., Heinemann, S., Carlisle, W. et al. Clonal cell lines from the rat central nervous system. Nature 249, 224–227 (1974). https://doi.org/10.1038/249224a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing