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Calcium uptake by sarcoplasmic reticulum of muscle from vitamin D-deficient rabbits


RECENT rapid advances in understanding the metabolism and action of vitamin D have confirmed its primary effect on intestinal calcium transport and continue to elucidate its action on bone and kidney1,2. Biochemical research has, however, largely neglected the well-known clinical observation of proximal muscle weakness in most vitamin D-deficient states3. Those studies which have been done provide only indirect evidence of a link between vitamin D and muscle. Thus, autoradiography after pharmacological doses of radioactive vitamin D has shown its localisation under the sarcolemma4, and when more physiological doses are given to rachitic animals, vitamin D and its metabolites may be found in significant amounts in muscle5. Skeletal muscle also contains a protein similar to the binding protein of kidney (but not of plasma) that binds 25-hydroxycholecalciferol6.

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CURRY, O., BASTEN, J., FRANCIS, M. et al. Calcium uptake by sarcoplasmic reticulum of muscle from vitamin D-deficient rabbits. Nature 249, 83–84 (1974).

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