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Selective pressure on HL-A polymorphism

Abstract

THE advantages of heterozygotes is one of the most frequent explanations of the maintenance of a polymorphism. This advantage may have the form of a lower fitness of all homozygotes, whatever the allele they possess. According to observations on a small Tuareg isolate, such is apparently the case for the polymorphism of the histocompatibility system HL-A.

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DEGOS, L., COLOMBANI, J., CHAVENTRE, A. et al. Selective pressure on HL-A polymorphism. Nature 249, 62–63 (1974). https://doi.org/10.1038/249062a0

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