Novel human serum protein from fibroblast plasma membrane

Article metrics


CELL surface components play a major role in the control of normal cell interactions and in the altered growth control and antigenic properties of malignant cells1. To characterise tissue-specific cell surface proteins we undertook an immunochemical study of the material released from cells by mild proteolytic treatment. Our studies have disclosed a fibroblast-specific cell surface and serum antigen in chicken2. The amount of this antigen is greatly reduced in chicken fibroblasts transformed by Rous sarcoma virus.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Burger, M. M., Current Topics in Cellular Regulation, 3, 135 (1972).

  2. 2

    Ruoslahti, E., Vaheri, A., Kuusela, P., and Linder, E., Biochim. biophys. Acta, 322, 352 (1973).

  3. 3

    Hayflick, L., and Moorhead, P. S., Expl Cell Res., 25, 585 (1961).

  4. 4

    Jacobs, J. P., Jones, C. M., and Baille, J. P., Nature, 227, 168 (1970).

  5. 5

    Hubbard, A. L., and Cohn, Z. A., J. Cell Biol., 55, 390 (1972).

  6. 6

    Martin, R. G., and Ames, B. N., J. biol. Chem., 236, 1372 (1961).

  7. 7

    Ruoslahti, E., and Seppälä, M., Int. J. Cancer, 8, 374 (1971).

  8. 8

    Charlton, R. K., and Zmijewski, C. M., Science, 170, 636 (1970).

  9. 9

    Thompson, D. M. P., Krupey, J., Freedman, S. O., and Gold, P., Proc. natn. Acad. Sci. U.S.A., 64, 161 (1969).

  10. 10

    Sjögren, H. O., Hellström, I., Bansal, S. C., and Hell-ström, K. E., Proc. natn. Acad. Sci. U.S.A., 68, 1372 (1971).

  11. 11

    Houck, J. C., Weil, R. L., and Sharma, V. K., Nature new Biol., 240, 210 (1972).

  12. 12

    Hellström, I., and Hellström, K. E., Nature, 240, 471 (1972).

  13. 13

    Moscona, A. A., J. cell. comp Physiol., supplement 1, 60, (1962).

  14. 14

    Garrod, D. R., and Steinberg, M. S., Nature, 244, 568 (1973).

  15. 15

    Goldschneider, I., and Moscona, A. A., J. Cell Biol., 53, 435 (1972).

  16. 16

    Vaheri, A., Ruoslahti, E., and Hovi, T., in ‘Control of proliferation in animal cells’ (edit. by Clarkson, B., and Baserga, R.) (Cold Spring Harbor Monograph, in the press).

  17. 17

    Vaheri, A., and Ruoslahti, E., Int. J. Cancer (in the press).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.