Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system


RECENT experiments1–3 indicate that cooperation between thymus derived lymphocytes (T cells) and antibody-forming cell precursors (B cells) is restricted by the H-2 gene complex. Helper activity in vivo operates only when T cells and B cells share at least one set of H-2 antigenic specificities. Evidence is presented here that the interaction of cytotoxic T cells with other somatic cells budding4–5 lymphocytic choriomeningitis (LCM) virus is similarly restricted.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout


  1. Kindred, B., and Shreffler, D. C., J. immun., 109, 940 (1972).

    CAS  PubMed  Google Scholar 

  2. Katz, D. H., Hamaoka, T., and Benacerraf, B., J. exp. Med., 137, 1405 (1973).

    Article  CAS  Google Scholar 

  3. Katz, D. H., Hamaoka, T., Dorf, M. E., and Benacerraf, B., Proc. natn. Acad. Sci., U.S.A., 70, 2624 (1973).

    Article  ADS  CAS  Google Scholar 

  4. Abelson, H. T., Smith, G. H., Hoffman, H. A., and Rowe, W. P., J. natn. Cancer Inst., 42, 497 (1969).

    CAS  Google Scholar 

  5. Kajima, M., and Majde, J., Naturwissenschaften, 57, 93 (1970).

    Article  ADS  CAS  Google Scholar 

  6. Zinkernagel, R. M., and Doherty, P. C., J. exp. Med., 138, 1266 (1973).

    Article  CAS  Google Scholar 

  7. Doherty, P. C., Zinkernagel, R. M., and Ramshaw, I. A., J. Immun. (in the press).

  8. Doherty, P. C., and Zinkernagel, R. M., Transpln. Rev., 18 (in the press).

  9. Marker, O., and Volkert, M., J. exp. Med., 137, 1511 (1973).

    Article  CAS  Google Scholar 

  10. Blanden, R. V., Mackaness, G. B., and Collins, F. M., J. exp. Med., 124, 585 (1966).

    Article  CAS  Google Scholar 

  11. Mims, C. A., and Subrahmanyan, T. P., J. Path. Bact., 91, 403 (1966).

    Article  CAS  Google Scholar 

  12. Cerottini, J.-C., Nordin, A. A., and Brunner, K. T., Nature, 228, 1308 (1970).

    Article  ADS  CAS  Google Scholar 

  13. Cerottini, J.-C., and Brunner, K. T., Adv. Immun. (in the press).

  14. Cole, G. A., Prendergast, R. A., and Henney, C. S., Fedn. Proc., 32, 964 (1973).

    Google Scholar 

  15. Hecht, T. T., and Summers, D. F., J. Virol., 10, 578 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Lengerova, A., Adv. Cancer Res., 16, 235 (1972).

    Article  CAS  Google Scholar 

  17. Perlmann, P., Perlmann, H., and Wigzell, H., Transpln. Rev., 13, 91 (1972).

    CAS  Google Scholar 

  18. MacLennan, I. C. M., Transpln. Rev., 13, 67 (1972).

    CAS  Google Scholar 

  19. Steele, R. W., Hensen, S. A., Vincent, M. M., Fuccillo, D. A., and Bellanti, J. A., J. Immun., 110, 1502 (1973).

    CAS  PubMed  Google Scholar 

  20. Hotchin, J., Monogr. Virol., 3, 1 (1971).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

ZINKERNAGEL, R., DOHERTY, P. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248, 701–702 (1974).

Download citation

  • Received:

  • Issue Date:

  • DOI:

This article is cited by


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing