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Zinc ions inhibit replication of rhinoviruses


THE rhinoviruses comprise a subgroup of the picornaviruses, distinguished by their acid lability. They are medically important as the infectious agents of the common cold in man. Although there have been reports of chemical agents which inhibit rhinovirus replication, in only a few instances has the mode of antiviral action been demonstrated at a biochemical level1,2.

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  1. Schleicher, J. B., Aquino, F. A., Rueter, A., Roderick, W. R., and Appell, R. N., Abstr. Tenth Interscience Conf. Antimicrobial Agents and Chemotherapy, Chicago, Abstr. No. 99 (1970).

  2. Matsumoto, S., Stanfield, F. J., Goore, M. Y., and Haff, R. F., Proc. Soc. exp. biol. Med., 139, 455 (1972).

    Article  CAS  Google Scholar 

  3. Vallee, B. L.,and Wacker, W. E. C., in The Proteins (edit. by Neurath, H.), 5, No. 22, 143 (Academic Press, New York, 1972).

    Google Scholar 

  4. Hughes, M. N., The Inorganic Chemistry of Biological Processes (Wiley, London, 1972).

    Google Scholar 

  5. Korant, B. D., Lonberg-Holm, K., Noble, J., and Stasny, J. T., Virology, 48, 71 (1972).

    Article  CAS  Google Scholar 

  6. Medappa, K. C., McLean, C., and Rueckert, R. R., Virology, 44, 259 (1971).

    Article  CAS  Google Scholar 

  7. McLean, C., and Rueckert, R. R., J. Virol., 11, 341 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Butterworth, B. E., Virology, 56, 439 (1973).

    Article  CAS  Google Scholar 

  9. Reviewed by Sugiyama, T., Korant, B. D., and Lonberg-Holm, K. K., A. Rev. Microbiol., 26, 467 (1972).

    Article  CAS  Google Scholar 

  10. Laemmli, U. K., Nature, 227, 680 (1970).

    Article  ADS  CAS  Google Scholar 

  11. Vogt, V. M., and Eisenman, R., Proc. natn. Acad., Sci. U.S.A., 70, 1734 (1973).

    Article  ADS  CAS  Google Scholar 

  12. Korant, B. D., J. Virol., 10, 751 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Summers, D. F., Shaw, E., Stewart, M. L.,and Maizel, J. V., J. Virol., 10, 880 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Korant, B. D., J. Virol., 12, 556 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

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KORANT, B., KAUER, J. & BUTTERWORTH, B. Zinc ions inhibit replication of rhinoviruses. Nature 248, 588–590 (1974).

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