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Inheritance of a recombinant HL-A haplotype and genetics of the HL-1 region in man


THE major histocompatibility system of man, designated HL-1, includes a series of closely linked genes of diverse functions1. HL-1 includes loci controlling two closely linked genes for the segregant series of HL-A antigens, genes responsible for the stimulation in mixed lymphocyte reactions (MLR-S) and possibly a genetic determinant (s) important for the induction of delayed-type hypersensitivity responses (HDR)2,3. Recombination between the genes for HL-A and between HL-A and MLR-S has been reported2,3.

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  1. Yunis, E. J., Seigler, H. F., Simmons, R. L., and Amos, D. B., Transplantation, 15, 435 (1973).

    Article  CAS  Google Scholar 

  2. Yunis, E. J., and Amos, D. B., Proc. natn. Acad. Sci., 68, 3031 (1971).

    Article  ADS  CAS  Google Scholar 

  3. Amos, D. B., and Yunis, E. J., Cell. Immun., 2, 517 (1971).

    Article  CAS  Google Scholar 

  4. Amos, D. B., Bashir, H., Boyle, W., MacQueen, M., and Tiilikainen, A., Transplantation, 7, 222 (1970).

    Google Scholar 

  5. Hartzman, R. J., Segal, M., Bach, M. L., and Bach, F. H., Transplantation, 11, 268 (1971).

    Article  CAS  Google Scholar 

  6. Plate, J. M., Ward, F. E., and Amos, D. B., in Histocompatibility Testing 1970 (edit. by Terasaki, P. I.), 531 (Munksgaard, Copensagen, 1970).

    Google Scholar 

  7. Yunis, E. J., Plate, J. M., Ward, F. E., Seigler, H. F., and Amos, D. B., Transplantn. Proc., 3, 118 (1971).

    CAS  Google Scholar 

  8. Dupont, B., Staub-Nielsen, L., and Svejgaard, A., Lancet, ii, 1336 (1971).

  9. Gatti, R. A., Meuwissen, H. J., Terasaki, P. I., and Good, R. A., Tissue Antigens, 1, 239 (1971).

    Article  CAS  Google Scholar 

  10. Histocompatibility Testing 1972, 3 (Munksgaard, Copenhagen, 1973).

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YUNIS, E., KRIVIT, W., REINSMOEN, N. et al. Inheritance of a recombinant HL-A haplotype and genetics of the HL-1 region in man. Nature 248, 517–519 (1974).

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