Abstract
MANY carbonyl compounds by virtue of the electron affinitive property1 of their C=O groups are good radiosensitisers in bacterial as well as mammalian cells2–4. The electronic charge distribution at the carbonyl bond of some local anaesthetics belonging to the class of esters represented by the general formula (I) given below is also known to play an important role in their anaesthetic action5–6. If these esters are found to be radiosensitisers they may prove very valuable in radiation therapy. Here we present data on one such compound, procaine hydrochloride (II) which is commonly used as a local anaesthetic and has been found to enhance radiation lethality of Escherichia coli B/r under anoxia.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Adams, G. E., and Dewey, D. L., Biochem. biophys. Res. Commun., 12, 473 (1963).
Adams, G. E., and Cooke, M. S., Int. J. radiat. Biol., 15, 457 (1969).
Adams, G. E., Asquith, J. C., Dewey, D. L., Foster, J. L., Michael, B. D., and Willson, R. L., Int. J. radiat. Biol., 19, 575 (1971).
Barnes, J. H., Ashwood-Smith, M. J., and Bridges, B. A., Int. J. radiat. Biol., 15, 285 (1969).
Wielding, S., and Tegner, C., Progr. Med. Chem., 3, 332 (1963).
Arens, E. J., Simonis, A. M., and Van Rossum, J. M., in Molecular Pharmacology (edit. by Arens, E, J.), 1, 119 (Academic, New York and London, 1964).
Butterworth, P. H. W., Baum, H., and Porter, J. W., Archs Biochem. Biophys., 118, 716 (1967).
Papahadjopoulos, D., Biochim. biophys. Acta., 265, 169 (1972).
Hauser, H., Penkett, S. A., and Chapman, D., Biochim. biophys. Acta, 183, 466 (1969).
Seeman, P., Sauks, T., Argent, W., and Kwant, W. O., Biochim. biophys. Acta, 183, 476 (1969).
Shenoy, M. A., Singh, B. B., and Gopal-Ayengar, A. R., Science, N.Y., 160, 999 (1968).
Shenoy, M. A., Joshi, D. S., Singh, B. B., and Gopal-Ayengar, A. R., Adv. biol. med. Phys. (edit by Lawrence, J. H. and Gofman, J. W.) 13, 255 (Academic, New York and London, 1970).
Shenoy, M. A., Mishra, K. P., Singh, B. B., and Gopal-Ayengar, A. R., Int. J. radiat. Biol. (in the press).
Powers, E. L., and Cross, M., Int. J. radiat. Biol., 17, 501 (1970).
Alper, T., in Biophysical Aspects of Radiation Quality, 171 (IAEA, Vienna, 1971).
Howard-Flanders, P., Adv. biol med. Phys. (edit by Tobias, C. A., and Lawrence, J. H.) 6, 533 (Academic, New York and London, 1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SHENOY, M., SINGH, B. & GOPAL-AYENGAR, A. Enhancement of radiation lethality of E. coli B/r by procaine hydrochloride. Nature 248, 415–416 (1974). https://doi.org/10.1038/248415a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/248415a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
