Letter | Published:

Seasonal Changes in Human Plasma Levels of 25-Hydroxyvitamin D

Naturevolume 247pages563565 (1974) | Download Citation

Subjects

Abstract

THE relative importance of the two alternative sources of vitamin D, endogenous skin synthesis by the action of solar ultraviolet rays and dietary ingestion, is uncertain in Britain. In the past, classical rickets was common in springtime but rare in autumn1,2, suggesting that summer sunshine was an important source of vitamin D. Seasonal variation in plasma antirachitic activity has been detected in more southerly latitudes in the United States, using bioassay techniques3, but data from Britain are scanty and some workers have considered the effects of sunshine to be minimal in this climate4. Possible age or sex differences in vitamin D nutritional status are also unknown.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Underwood, M., A Treatise on the Disease of Children, 1, 313 (1789).

  2. 2

    Schmorl, G., Ergebn. inn. Med. Kinderheilk, iv, 403 (1909).

  3. 3

    Smith, R. W., jun. Rizek, J., and Frame, B., Am. J. clin. Nutr., 14, 98 (1964).

  4. 4

    Lumb, G. A., Mawer, E. B., and Stanbury, S. W., Am. J. Med., 50, 421 (1971).

  5. 5

    De Luca, H. F., Recent Prog. Horm. Res., 27, 479 (1971).

  6. 6

    Haddad, J. G., and Chyu, K. J., J. clin. Endoc. Metab., 33, 992 (1971).

  7. 7

    Round, J. M., Br. med. J., 3, 137 (1973).

  8. 8

    Stamp, T. C. B., and Round, J. M., Br. med. J., 2, 551 (1973).

  9. 9

    Haddad, jun., J. G., Chyu, K. J., Hahn, T. J., and Stamp, T. C. B., J. Lab. clin. Med., 81, 22 (1973).

  10. 10

    Haddad, J. G., Nature, 244, 515 (1973).

  11. 11

    Dent, C. E., Round, J. M., Rowe, D. J. F., and Stamp, T. C. B., Lancet, i, 1282 (1973).

Download references

Author information

Affiliations

  1. Department of Human Metabolism, University College Hospital and Medical School, London, WCl

    • T. C. B. STAMP
    •  & J. M. ROUND

Authors

  1. Search for T. C. B. STAMP in:

  2. Search for J. M. ROUND in:

About this article

Publication history

Received

Issue Date

DOI

https://doi.org/10.1038/247563a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.