Letter | Published:

Immunosuppressive Effect of an Anti-interferon Serum

Naturevolume 247pages551552 (1974) | Download Citation

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Abstract

INTERFERON has been reported to play an important role in immune responses1–6. Using interferon3,5,6 acceleration of mouse skin allograft rejection has been demonstrated in addition to an increase in the cytotoxic action of lymphocytes on appropriate target cells in vitro. It has also been shown that prolongation of skin allografts can be achieved by the use of anti-interferon serum3. To further test the possibility of involvement of interferon in immune responses an attempt is here described to block the interferon effect by anti-interferon serum.

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References

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    Green, J. A., Cooperband, S. R., and Kibrick, S., Science, N.Y., 164, 1415 (1969).

  2. 2

    Green, J. A., Cooperband, S. R., Lourence, F. R., and Kibrick, S., Ann. N.Y. Acad. Sci., 173, 736 (1970).

  3. 3

    Skurkovich, S. V., Klinova, E. G., Alexandrovskaya, I. M., Levina, N. V., Arkhipova, N. A., and Bulycheva, T. I., Proc. Thirteenth I.S.B.T. Cong., Washington (1972).

  4. 4

    Skurkovich, S. V., and Alexandrovskaya, I. M., Probl. Gematol. (in Russian), 3, 34 (1973).

  5. 5

    Skurkovich, S. V., Klinova, E. G., Alexandrovskaya, I. M., Levina, N. V., Arkhipova, N. A., and Bulycheva, T. I., Bull. exp. Biol. (in Russian), 4, 66 (1973).

  6. 6

    Skurkovich, S. V., Klinova, E. G., Alexandrovskaya, I. M., Levina, N. V., Arkhipova, N. A., and Bulycheva, T. I., Immunology, 25, 317 (1973).

  7. 7

    Terasaki, P. I., and McClelland, J. D., Nature, 204, 998 (1964).

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Affiliations

  1. Central Institute of Haematology and Blood Transfusion, Moscow

    • S. V. SKURKOVICH
    • , E. G. KLINOVA
    • , E. I. EREMKINA
    •  & N. V. LEVINA

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https://doi.org/10.1038/247551a0

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