Letter | Published:

Prostaglandin E2 as stimulator of haemopoietic stem cell proliferation

Naturevolume 247pages550551 (1974) | Download Citation

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Abstract

ALTHOUGH a strict correlation between prostaglandins and the cyclic AMP system has been suggested for several cell types, and the mitogenic effect of cyclic AMP has also been proved1,2, the mitotic effect of prostaglandins has been demonstrated only for some cell systems3. Also, little is known about the haemopoietic effect of prostaglandins. As proved by Dukes4, several prostaglandins, especially PGE2, enhance the 59Fe and 14C-glucosamine incorporation into bone marrow cells and potentiate the effect of erythropoietin, in vitro. We have studied the effect of PGE2 on the proliferative state of haemopoietic stem cells (spleen colony forming units:CFU).

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References

  1. 1

    Byron, J. W., Nature, 234, 39 (1971).

  2. 2

    Rixon, R. H., Whitfield, J. F., and MacManus, J. P., Expl Cell Res., 63, 110 (1970).

  3. 3

    Franks, D. J., MacManus, J. P., and Whitfield, J. F., Biochem. biophys. Res Commun., 44, 1177 (1971).

  4. 4

    Dukes, P. P., Int. Conf. Prostaglandins, in Adv. Biosci., 9, 183, (1972).

  5. 5

    Lajtha, L. G., J. cell. comp. Physiol. (Suppl. 1), 62, 143 (1963).

  6. 6

    Becker, A. J., McCulloch, E. A., Siminovitch, L., and Till, J. E., Blood, 26, 296 (1965).

  7. 7

    Till, J. E., and McCulloch, E. A., Radiat. Res., 14, 213 (1961).

  8. 8

    Novogrodsky, A., and Katchalski, E., Biochim. biophys. Acta, 215, 291 (1970).

  9. 9

    Robinson, G. A., Arnold, A., and Hartmann, R. C., Pharmac. Res. Commun., 1, 325 (1969).

  10. 10

    Robinson, G. A., Butcher, R. W., and Sutherland, E. W., Fundamental concepts of drug-receptor interactions (edit. by Danielli, J. F., Morgan, J. F., and Triggle, D. J.), 59 (Academic Press, New York 1970).

  11. 11

    Hertelendy, F., Woods, and Jaffe, B. M., Prostaglandins, 3, 223 (1973).

  12. 12

    Byron, J. W., Expl Cell Res., 71, 228 (1972).

  13. 13

    Sheppard, J. R., Nature new Biol., 236, 14 (1972).

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Affiliations

  1. ‘Frédéric Joliot-Curie’, National Research Institute for Radiobiology and Radiohygiene, Budapest, 22

    • I. FEHÉR
    •  & JULIA GIDÁLI

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https://doi.org/10.1038/247550a0

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