Letter | Published:

Prostaglandins as Mediators of Reactive Hyperaemia in Kidney

Naturevolume 247page492 (1974) | Download Citation

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Abstract

SEVERAL mechanisms have been proposed to account for the reactive hyperaemia which follows arterial occlusion in the kidney, including the intrarenal production of a vasodilator substance1,2. Recent work shows that the local generation of a prostaglandin can cause vasodilatation in the kidney3,4 and can contribute to autoregulation of renal blood flow5,6. We have therefore used a prostaglandin synthetase inhibitor, indomethacin7, to test whether the reactive hyperaemia which follows release of renal artery occlusion is mediated by a prostaglandin mechanism.

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References

  1. 1

    Hinshaw, L. B., Page, B. B., Brake, C. M., and Emerson, T. E., Am. J. Physiol., 205, 1033 (1963).

  2. 2

    Honda, N., Aizawa, C., and Yosnitoshi, Y., Am. J. Physiol., 215, 190 (1968).

  3. 3

    Aiken, J. W., and Vane, J. R., J. Pharm. exp. Ther., 184, 678 (1973).

  4. 4

    Lonigro, A. J., Terragno, N. A., Malik, K. U., and McGiff, J. C., J. lab. clin. Med., 78, 1016 (1971).

  5. 5

    Herbaczynska-Cedro, K., and Vane, J. R., Proc. fifth int. pharmac. Congress. Abstr., p. 596.

  6. 6

    Herbaczynska-Cedro, K., and Vane, J. R., Circ. Res., 33, 428 (1973).

  7. 7

    Vane, J. R., Nature new Biol., 231, 232 (1971).

  8. 8

    Lonigro, A. J., Itskovitz, H. D., Crowshaw, K., and McGiff, J. C., Circ. Res., 32, 1712 (1973).

  9. 9

    McGiff, J. C., Crowshaw, K., Terragno, N. A., Lonigro, A. J., Strand, J. C., Williamson, M. A., Lee, J. B., and Ng, K. K. F., Circ. Res., 27, 765 (1970).

  10. 10

    Lee, J. B., Prostaglandins, 3, 551 (1973).

  11. 11

    Papanicolaou, N., Experientia, 28, 275 (1972).

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Author notes

    • K. HERBACZYNSKA-CEDRO

    Present address: Experimental and Clinical Medical Research Centre, Polish Academy of Sciences, Dwarkowa, 3, Warsaw

    • J. R. VANE

    Present address: Wellcome Research Laboratories, Langley Court, Beckenham, Kent

Affiliations

  1. Department of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons of England, Lincoln's Inn Fields, London, WC2A 3PN

    • K. HERBACZYNSKA-CEDRO
    •  & J. R. VANE

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https://doi.org/10.1038/247492a0

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