Abstract
MOST of the in vitro systems that have been developed to study the mechanisms of chemical carcinogenesis use rodent fibroblasts grown in culture1–3. Since they are rapid and permit the control of many parameters, these in vitro malignant transformation techniques offer advantages over the in vivo procedures previously employed.
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LASNE, C., GENTIL, A. & CHOUROULINKOV, I. Two-stage Malignant Transformation of Rat Fibroblasts in Tissue Culture. Nature 247, 490–491 (1974). https://doi.org/10.1038/247490a0
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DOI: https://doi.org/10.1038/247490a0
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