Abstract
IT has been demonstrated that the antifungal lipophylic polyene amphotericin B inhibits eukaryotic cell growth by binding to sterols and making ‘holes’ in cell membranes1. Used at subinhibitory concentrations, it enhances penetration of other antibiotics into the cells of higher organisms in vitro and in vivo, showing a synergistic effect with a number of unrelated drugs1,2. It has also been demonstrated that higher doses of amphotericin B inhibit macromolecular syntheses, probably by severely damaging the cell membrane3.
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References
Kinsky, S. C., A. Rev. Pharmac., 10, 119 (1970).
Hackett, A. J., Sylvester, S. S., Joss, V. R., and Calvin, M., Proc. natn. Acad. Sci. U.S.A., 69, 3653 (1972).
Medoff, G., Kwan, C. N., Schlessinger, D., and Kobayashi, G. S., Antimicrob. Ag. Chemother., 3, 441 (1973).
Medoff, G., Kobayashi, G. S., Schlessinger, D., and Valeriote, F. A., Science N.Y. (in the press).
MacPherson, I., and Montagnier, L., Virology, 23, 292 (1964).
Pollack, R. E., Green, H., and Todaro, G. J., Proc. natn. Acad. Sci. U.S.A., 60, 126 (1968).
Littlefield, J. W., Science, N.Y., 145, 709 (1964).
Labella, T., Amati, P., and Marin, G., J. cell. comp. Physiol., 81, 347 (1973).
Migeon, B. R., Biochem. Genet., 1, 305 (1968).
Todaro, G. J., and Green, H., J. Cell Biol., 17, 299 (1963).
Basilico, C., Matsuya, Y., and Green, H., J. Virol., 3, 140 (1969).
Marin, G., and Pugliatti-Crippa, L., Expl. Cell Res., 70, 253 (1972).
Todaro, G. J., and Green, H., Science, N.Y., 147, 513 (1965).
Littlefield, J. W., and Basilico, C., Nature, 211, 250 (1966).
Marin, G., and Littlefield, J. W., J. Virol., 2, 69 (1968).
Westerveld, A., Meera Khan, P., Visser, R. P. L. S., and Bootsma, D., Nature, 234, 24 (1971).
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AMATI, P., LAGO, C. Sensitivity to Amphotericin B of in vitro Established Cell Lines. Nature 247, 466–469 (1974). https://doi.org/10.1038/247466a0
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DOI: https://doi.org/10.1038/247466a0
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