Letter | Published:

Discrimination learning in ascorbic acid-deficient guinea pigs

Naturevolume 247page398 (1974) | Download Citation



PAULING1 has suggested that a high intake of vitamin C may be necessary for optimum cerebral function including learning and memory. We have tested this hypothesis in a preliminary way by comparing maze learning in two groups of guinea pigs: those receiving large supplements of ascorbic acid (the ‘control’ group) and those receiving a daily quantity of the vitamin sufficient to maintain a concentration in the brain at approximately 25% that of the controls (the ‘deficient’ group).

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  1. 1

    Pauling, L., Science N.Y., 160, 265 (1968).

  2. 2

    Hughes, R. E., and Hurley, R. J., Br. J. Nutr., 23, 211 (1969).

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    Burch, H. B., Ann. N.Y. Acad. Sci., 92, 268 (1961).

  4. 4

    Williams, R. S., and Hughes, R. E., Br. J. Nutr., 28, 167 (1972).

  5. 5

    Roe, J. H., and Kuether, C. A., J. biol. Chem., 147, 399 (1943).

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  1. Department of Child Health, University of Manchester, Clinical Sciences Building, York Place, Manchester, M13 OJJ

    • B. P. F. ADLARD
    • , SUSAN MOON
    •  & J. L. SMART


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