Letter | Published:

Proliferative Capacity of Human Alveolar Macrophage

Naturevolume 247pages373375 (1974) | Download Citation

Subjects

Abstract

THE alveolar macrophage plays a crucial role in the pulmonary ecology and is a first line of cellular defence for the lung1,2. Although animal studies indicate that pulmonary macrophages originate from the bone marrow3–5, little is known of the origin or fate of these cells in man. Cigarette smokers, however, are known to have substantially increased numbers of macrophages in the lung1,6 and the pulmonary macrophages in smokers demonstrate characteristic morphologic and functional attributes1,2,7,8.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Harris, J. O., Swenson, E. W., and Johnson, III, J. E., J. clin Invest., 49, 2086 (1970).

  2. 2

    Cohen, A. B., and Cline, M. J., J. clin. Invest., 50, 1390 (1971).

  3. 3

    Godleski, J. J., and Brain, J. D., J. exp. Med., 136, 630 (1972).

  4. 4

    Virolainen, M., J. exp. Med., 127, 943 (1968).

  5. 5

    Brunstetter, M. A., Hardies, J. A., Schiff, R., Lewis, J. P., and Cross, C. E., Archs. intern. Med., 127, 1065 (1971).

  6. 6

    Pratt, S. A., Finley, T. N., Smith, M. H., et al., Anat. Rec., 163, 497 (1969).

  7. 7

    Pratt, S. A., Smith, M. H., Ladman, A. J., and Finley, T. N., Lab. Invest., 24, 331 (1971).

  8. 8

    Mann, P. E. G., Cohen, A. B., Finley, T. N., and Ladman, A. J., Lab. Invest., 25, 111 (1971).

  9. 9

    Finley, T. N., and Ladman, A. J., New Engl. J. Med., 286, 223 (1972).

  10. 10

    Golde, D. W., Finley, T. N., and Cline, M. J., Lancet, ii, 1397 (1972).

  11. 11

    Golde, D. W., and Cline, M. J., Blood, 41, 45 (1973).

  12. 12

    Cleaver, J. E., Rad. Res., 37, 334 (1969).

  13. 13

    Ansley, H., and Ornstein, L., Adv. Automated Anal., 1, 5 (1970).

  14. 14

    Golde, D. W., and Cline, M. J., J. clin. Invest., 51, 2981 (1972).

  15. 15

    Evans, M. J., Cabral, L. J., Stephens, B. J., and Freeman, G., Am. J. Path., 70, 199 (1973).

  16. 16

    Kelly, L. S., and Dobson, E. L., Br. J. exp. Path., 52, 88 (1971).

  17. 17

    Bowden, D. H., and Adamson, I. Y., Am. J. Path., 68, 521 (1972).

  18. 18

    Vernon-Roberts, B., The Macrophages: Biological Structure and Function (edit. by Harrison, R. J., and McMinn, R. M. H.), 2 (Cambridge University Press, 1972).

Download references

Author information

Author notes

    • DAVID W. GOLDE

    Present address: Division of Hematology/Oncology, UCLA Center for the Health Sciences, Los Angeles, California, 90024

Affiliations

  1. Cancer Research Institute, University of California, San Francisco, California, 94143

    • DAVID W. GOLDE
    •  & LISKEN A. BYERS
  2. Pulmonary Division, Mt. Zion Hospital and Medical Center, San Francisco, California, 94115

    • THEODORE N. FINLEY

Authors

  1. Search for DAVID W. GOLDE in:

  2. Search for LISKEN A. BYERS in:

  3. Search for THEODORE N. FINLEY in:

About this article

Publication history

Received

Issue Date

DOI

https://doi.org/10.1038/247373a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.