Letter | Published:

Proliferative Capacity of Human Alveolar Macrophage

Naturevolume 247pages373375 (1974) | Download Citation



THE alveolar macrophage plays a crucial role in the pulmonary ecology and is a first line of cellular defence for the lung1,2. Although animal studies indicate that pulmonary macrophages originate from the bone marrow3–5, little is known of the origin or fate of these cells in man. Cigarette smokers, however, are known to have substantially increased numbers of macrophages in the lung1,6 and the pulmonary macrophages in smokers demonstrate characteristic morphologic and functional attributes1,2,7,8.

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    Present address: Division of Hematology/Oncology, UCLA Center for the Health Sciences, Los Angeles, California, 90024


  1. Cancer Research Institute, University of California, San Francisco, California, 94143

    •  & LISKEN A. BYERS
  2. Pulmonary Division, Mt. Zion Hospital and Medical Center, San Francisco, California, 94115



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