Letter | Published:

Binding of thrombin to human platelets

Naturevolume 247pages306307 (1974) | Download Citation



MUCH work has been carried out aimed at elucidating the mode of action of thrombin on platelets1–5. These studies were based on the assumption that hydrolysis of a protein by thrombin constitutes the primary event culminating in aggregation of platelets. Results of recent studies suggest that the primary step in this process might be binding of thrombin to a receptor site, triggering viscous metamorphosis of the platelets6,7. The processes of binding and proteolysis need not be mutually exclusive, however, binding may be followed by proteolysis. Here I present direct evidence of thrombin binding by human platelets and discuss some of its implications.

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  1. Laboratory of Hematology St. Jude Children's Research Hospital Memphis, Tennessee, 38101

    • P. GANGULY


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